Three Brothers of Mary (Marianist) from Dayton, Ohio, arrived in Wailuku to staff St. Anthony Boys School in 1883.

In 1884, the Franciscan Sisters of Syracuse arrived to take charge of the St. Anthony Girls School. The Marianist Brothers constructed a new 10 classroom school along with a spacious residence in 1925.

The Maryknoll Sisters arrived to staff St. Anthony Girls School from 1928 until 1980. From 400 pupils in 1928, the school's enrollment rose to 1900 pupils. The new Girls High School was completed in 1940 and the present St. Anthony Grade School Building was dedicated on 1955.

In 1971 the intermediate grades seventh and eight were added to the high school, now referred to as St. Anthony Junior Senior High School.  The preschool building was built in 1974.

In August of 1978, Brother Clarence Chew, S.M. became the first Marianist principal of St. Anthony Grade School.  Brother Richard Britton, S.M. until 1985 followed his term.

In August of 1985, Sister Margaret Leonard Perreira, C.S.J. of the Sisters of St. Joseph of Carondelet accepted the administration of St. Anthony Grade School.

At present a lay principal with the help of a dedicated lay faculty staffs St. Anthony Grade School.

St. Anthony Grade School operates under the auspices of the Bishop of the Catholic Diocese of Honolulu. It is licensed by the State of Hawaii and is a member of the National Catholic Education Association. The Western Association of Schools and Colleges and the Western Catholic Educational Association accredit St. Anthony Grade School.